Pre-clinical modeling of cutaneous melanoma.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32504051.
- Also identified by DOI 10.1038/s41467-020-15546-9 and PMC identifier 7275051.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes melanoma as an ideal model for investigating therapy resistance. In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft. In particular, we highlight how each system recapitulates different features of melanoma adaptability and can be used to better understand melanoma development, progression and therapy resistance.
Medical subject headings
- Antinematodal Agents
- Disease Models, Animal
- Melanoma
- Skin Neoplasms
- Xenograft Model Antitumor Assays