What is the role of supplementation with ascorbic acid, zinc, vitamin D, or <i>N</i>-acetylcysteine for prevention or treatment of COVID-19?

Bauer, Seth R; Kapoor, Aanchal; Rath, Mary; Thomas, Suma A · Cleve Clin J Med · 2020

review · Level V

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Abstract

Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin D, and <i>N</i>-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. The authors outline the biologic plausibility, applicable clinical data, and potential role of each of these agents.