Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32555157.
- Also identified by DOI 10.1038/s41467-020-16924-z and PMC identifier 7303218.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.
Medical subject headings
- Carotid Arteries
- Fluorescent Dyes
- Hindlimb
- Reperfusion Injury
- Thrombosis
- Vascular Diseases