Induced pluripotent stem cells provide mega insights into kidney disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32571490.
- Also identified by DOI 10.1016/j.kint.2020.04.033 and PMC identifier 8204406.
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Abstract
Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal system into the spotlight, as it is proposed to play a central role in the regulation of megalin in health and disease.
Medical subject headings
- Induced Pluripotent Stem Cells
- Kidney Diseases