Adhesion-stabilizing long-distance transport of cells on tissue surface.

Abstract

The stable transport of migrating eukaryotic cells is essential in organ development and repair processes. However, the mechanism that preserves transport stability over long distances in organs is not fully understood. As the driving mechanism of cell migration, the expressions of heterophilic cell-cell adhesion between moving cells and scaffolding tissue have been observed in such transport. In this paper, we theoretically investigate this heterophilic adhesion, which is persistently polarized in the migrating cell, as a possible transport stabilization mechanism. The adhesion was examined on the basis of the cellular Potts model, and our results confirm the stabilization of the transport to be an effect of the persistence.