Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 32582936.
- Also identified by DOI 10.1093/infdis/jiaa349 and PMC identifier 7337874.
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Abstract
In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.
Medical subject headings
- Amine Oxidase (Copper-Containing)
- Betacoronavirus
- Cell Adhesion Molecules
- Chemokine CX3CL1
- Coronavirus Infections
- Intercellular Adhesion Molecule-1
- Pneumonia, Viral
- Vascular Cell Adhesion Molecule-1