Looking backward in time to define the chronology of metastasis.

Hu, Zheng; Curtis, Christina · Nat Commun · 2020

review · Level V

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Abstract

The timing of cancer metastasis has implications for treatment and prevention. Traditional forward-time views of metastasis assume it occurs late during evolution. However, looking backward in time reveals metastasis often occurs prior to clinical detection of primary tumors.

Medical subject headings