SnapShot: Jak-STAT Signaling II.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32589961.
- Also identified by DOI 10.1016/j.cell.2020.04.052 and PMC identifier 11533724.
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Abstract
The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).
Medical subject headings
- Janus Kinases
- STAT Transcription Factors