Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors.

Leegwater, Emiel; Strik, Anne; Wilms, Erik B; Bosma, Liesbeth B E; Burger, David M; Ottens, Thomas H; van Nieuwkoop, Cees · Clin Infect Dis · 2021

case_report · Level V

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Abstract

We report a case of a man with COVID-19 who developed acute hepatotoxicity related to remdesivir with probable interaction of P-glycoprotein (P-gp) inhibitors. Until further details on this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy.

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