Is Obesity a Disease of Stem Cells?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32619511.
- Also identified by DOI 10.1016/j.stem.2020.04.019 and PMC identifier 8715393.
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Abstract
Obesity disrupts physiological homeostasis and alters both systemic and local microenvironments that impact stem cell plasticity and impair regenerative capacity. We present growing evidence that reveals the bidirectionality of obesity-induced stem cell dysfunction and how the molecular changes in stem cells residing in obese environments may accelerate disease severity.
Medical subject headings
- Obesity
- Stem Cells