Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32619519.
- Also identified by DOI 10.1016/j.stem.2020.06.012.
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Abstract
Many type 2 diabetes patients develop cardiovascular disease (CVD) while some are protected. Toyohara et al. (2020) find that elevated arylacetamide deacetylase (AADAC) expression in vascular smooth muscle cells (dVSMCs) differentiated from patient-derived induced pluripotent stem cells is associated with cardioprotection. AADAC overexpression alters multiple dVSMC properties and decreases murine CVD.
Medical subject headings
- Atherosclerosis
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Induced Pluripotent Stem Cells