A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 32632093.
- Also identified by DOI 10.1038/s41467-020-17002-0 and PMC identifier 7338361.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (N<sub>cases</sub>/N<sub>controls</sub> = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, r<sub>g</sub> = 0.11, P = 3.56 × 10<sup>-06</sup>) and systolic BP (SBP, r<sub>g</sub> = 0.06, P = 0.01), but not pulse pressure (PP, r<sub>g</sub> = -0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10<sup>-08</sup>), nine of which replicate (P < 0.05) in the UK Biobank. Five shared loci (ITGB5, SMG6, ADRA2B, ANKDD1B, and KIAA0040) are reinforced in gene-level analysis and highlight potential mechanisms involving vascular development, endothelial function and calcium homeostasis. Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15-1.25]/10 mmHg; P = 5.57 × 10<sup>-25</sup>) on migraine than SBP (1.05 [1.03-1.07]/10 mmHg; P = 2.60 × 10<sup>-07</sup>) and a corresponding opposite effect for PP (0.92 [0.88-0.95]/10 mmHg; P = 3.65 × 10<sup>-07</sup>). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.
Medical subject headings
- Blood Pressure
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Meta-Analysis as Topic
- Migraine Disorders
- Polymorphism, Single Nucleotide