Muscle-derived Myoglianin regulates <i>Drosophila</i> imaginal disc growth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32633716.
- Also identified by DOI 10.7554/eLife.51710 and PMC identifier 7371420.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In <i>Drosophila,</i> the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.
Medical subject headings
- Drosophila Proteins
- Drosophila melanogaster
- Imaginal Discs
- Smad Proteins, Receptor-Regulated
- Transforming Growth Factor beta