Biological functions of lymphatic vessels.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32646971.
- Also identified by DOI 10.1126/science.aax4063.
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Abstract
The general functions of lymphatic vessels in fluid transport and immunosurveillance are well recognized. However, accumulating evidence indicates that lymphatic vessels play active and versatile roles in a tissue- and organ-specific manner during homeostasis and in multiple disease processes. This Review discusses recent advances to understand previously unidentified functions of adult mammalian lymphatic vessels, including immunosurveillance and immunomodulation upon pathogen invasion, transport of dietary fat, drainage of cerebrospinal fluid and aqueous humor, possible contributions toward neurodegenerative and neuroinflammatory diseases, and response to anticancer therapies.
Medical subject headings
- Immunologic Surveillance
- Lymphatic Vessels