Bacteria SAVED from Viruses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32649879.
- Also identified by DOI 10.1016/j.cell.2020.06.015.
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Abstract
Increasingly, cyclic nucleotide second messengers are implicated in antiviral defense systems in bacteria and archaea as well as in eukaryotes. In this issue of Cell, Lowey et al. describe SAVED-a widespread, uncharacterized cyclic nucleotide sensor protein domain that activates cell defense systems. The structure of SAVED reveals links to the CRISPR system, which also generates cyclic nucleotides in response to viral infection.
Medical subject headings
- Bacteriophages
- Viruses