Ex Vivo Analysis of a Porcine Bicuspid Aortic Valve and Aneurysm Disease Model.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 32663472.
- Also identified by DOI 10.1016/j.athoracsur.2020.05.086 and PMC identifier 8357412.
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Abstract
We identified an extremely rare congenital porcine type 0 lateral bicuspid aortic valve from a fresh porcine heart. Using a 3-dimensionally printed ex vivo left heart simulator, we analyzed valvular hemodynamics at baseline, in an aortic aneurysm disease model, and after valve-sparing root replacement. We showed that bicuspid aortic valve regurgitation due to aortic aneurysm can be successfully repaired without significant hemodynamic impairment using the valve-sparing root replacement technique in an individualized approach. Our results provide direct hemodynamic evidence supporting the use of valve-sparing root replacement for patients with bicuspid aortic valve regurgitation.
Medical subject headings
- Aortic Aneurysm, Thoracic
- Aortic Valve
- Bicuspid Aortic Valve Disease
- Cardiac Surgical Procedures