Transplacental transmission of SARS-CoV-2 infection.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 32665677.
- Also identified by DOI 10.1038/s41467-020-17436-6 and PMC identifier 7360599.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.
Medical subject headings
- Coronavirus Infections
- Infectious Disease Transmission, Vertical
- Pneumonia, Viral
- Pregnancy Complications, Infectious
- Vasculitis, Central Nervous System