Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 32668454.
- Also identified by DOI 10.1093/infdis/jiaa426 and PMC identifier 7938177.
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Abstract
Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses. This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012-2017 were categorized by symptom status. Antibody response was assessed using hemagglutination inhibition assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in HAI antibodies, and 75.3% had febrile illness. In a logistic regression model, febrile cases had 2.17 times higher odds of a ≥4-fold titer rise compared to asymptomatic cases (95% confidence interval, 1.02-4.64). Studies relying on serological assays may not generalize to asymptomatic infections.
Medical subject headings
- Antibodies, Viral
- Hemagglutination Inhibition Tests
- Influenza, Human