Can Molecular Imaging Measure T-cell Activation?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32669349.
- Also identified by DOI 10.1158/0008-5472.CAN-20-1146.
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Abstract
Successful immunotherapy usually depends on activation of T cells in the tumor microenvironment. However, ascertaining whether T-cell activation has occurred <i>in vivo</i> is difficult without invasive tissue sampling. Inducible T-cell costimulator (ICOS) is a specific marker of T-cell activation that can be imaged by radiolabeling an anti-ICOS antibody and performing PET scanning. Hopefully, this agent will be the first of many molecular imaging constructs that can determine whether T-cell activation has occurred and could be used in drug development and clinical trials of cancer immunotherapy.<i>See related article by Xiao et al., p. 3023</i>.
Medical subject headings
- Molecular Imaging
- Neoplasms