Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32672790.
- Also identified by DOI 10.1093/cid/ciaa1007 and PMC identifier 7454379.
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Abstract
Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.
Medical subject headings
- COVID-19
- Vascular Endothelial Growth Factor Receptor-1