Individualized PEEP to optimise respiratory mechanics during abdominal surgery: a pilot randomised controlled trial.

Abstract

Higher intraoperative driving pressures (ΔP) are associated with increased postoperative pulmonary complications (PPC). We hypothesised that dynamic adjustment of PEEP throughout abdominal surgery reduces ΔP, maintains positive end-expiratory transpulmonary pressures (P_{tp_ee}) and increases respiratory system static compliance (C_rs) with PEEP levels that are variable between and within patients. In a prospective multicentre pilot study, adults at moderate/high risk for PPC undergoing elective abdominal surgery were randomised to one of three ventilation protocols: (1) PEEP≤2 cm H₂O, compared with periodic recruitment manoeuvres followed by individualised PEEP to either optimise respiratory system compliance (PEEP_maxCrs) or maintain positive end-expiratory transpulmonary pressure (PEEP_{Ptp_ee}). The composite primary outcome included intraoperative ΔP, P_{tp_ee}, C_rs, and PEEP values (median (interquartile range) and coefficients of variation [CV_PEEP]). Thirty-seven patients (48.6% female; age range: 47-73 yr) were assigned to control (PEEP≤2 cm H₂O; n=13), PEEP_maxCrs (n=16), or PEEP_{Ptp_ee} (n=8) groups. The PEEP_{Ptp_ee} intervention could not be delivered in two patients. Subjects assigned to PEEP_maxCrs had lower ΔP (median8 cm H₂O [7-10]), compared with the control group (12 cm H₂O [10-15]; P=0.006). PEEP_maxCrs was also associated with higher P_{tp_ee} (2.0 cm H₂O [-0.7 to 4.5] vs controls: -8.3 cm H₂O [-13.0 to -4.0]; P≤0.001) and higher C_rs (47.7 ml cm H₂O [43.2-68.8] vs controls: 39.0 ml cm H₂O [32.9-43.4]; P=0.009). Individualised PEEP (PEEP_maxCrs and PEEP_{Ptp_ee} combined) varied widely (median: 10 cm H₂O [8-15]; CV_PEEP=0.24 [0.14-0.35]), both between, and within, subjects throughout surgery. This pilot study suggests that individualised PEEP management strategies applied during abdominal surgery reduce driving pressure, maintain positive P_{tp_ee} and increase static compliance. The wide range of PEEP observed suggests that an individualised approach is required to optimise respiratory mechanics during abdominal surgery. NCT02671721.