Multifocal Calcifying Fibrous Tumor at Seven Intrathoracic Sites in One Patient.

Hernandez, Moises; Lin, Grace; Zhang, Yu; Rajabnejad, Ataollah; Balistrieri, Francesca; Thistlethwaite, Patricia · Ann Thorac Surg · 2021

case_report · Level V

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Abstract

Calcifying fibrous tumors are rare lesions that occur throughout the body. A 35-year-old man presented with exertional dyspnea. Computed tomography showed a polypoid mass abutting pericardium, diaphragm, and left chest wall, and a pleural-based lesion adjacent to T12. Thoracoscopy revealed a large mass with diaphragmatic stalk, two pleural-based nodules, and four diaphragmatic nodules. Pathologic analysis of resected lesions showed calcifying fibrous tumors. Three lesions contained heterogenous mutations associated with this tumor type. The patient is disease free 1 year later. Calcifying fibrous tumors should be recognized as rare multifocal pleural and diaphragmatic-based tumors. Complete resection leads to excellent survival for patients with this uncommon disease.

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