Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 32686825.
- Also identified by DOI 10.1093/cid/ciaa1011 and PMC identifier 8315126.
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Abstract
Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.
Medical subject headings
- Anti-HIV Agents
- HIV Infections
- Pharmaceutical Preparations
- Pre-Exposure Prophylaxis