Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 32687164.
- Also identified by DOI 10.1093/cid/ciaa1015.
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Abstract
Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.
Medical subject headings
- Cell-Free Nucleic Acids
- Hepatitis B
- Hepatitis B, Chronic