Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32703951.
- Also identified by DOI 10.1038/s41467-020-17594-7 and PMC identifier 7378234.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.
Medical subject headings
- Blood Vessels
- Leukemia, Myeloid, Acute