Coming out of the PiTs-novel strategies for controlling intestinal phosphate absorption in patients with CKD.

Abstract

The kidneys are the gatekeepers of phosphate balance, and loss of kidney function causes a profound disturbance of mineral metabolism. Patients with chronic kidney disease suffer from an excessive cardiovascular disease risk with a high morbidity and mortality. Current therapies aimed at reducing total phosphate body load are insufficient, and novel strategies are urgently needed. In this issue, Tsuboi and colleagues provide evidence for the use of a novel phosphate transporter inhibitor to reduce intestinal phosphate absorption.