Peptide-induced RAFT polymerization via an amyloid-β<sub>17-20</sub>-based chain transfer agent.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32717010.
- Also identified by DOI 10.1039/d0sm01169j.
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Abstract
We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-β (Aβ) protein core sequence Leu-Val-Phe-Phe (LVFF, Aβ17-20) via RAFT polymerization. Based on a novel chain transfer-agent, the "grafting-from" approach effectively generates the well-defined peptide-polymer conjugates with appreciably high monomer conversion rate, resulting in mechanically stiffer peptide-functional cross-linked polymeric hydrogels.
Medical subject headings
- Amyloid beta-Peptides
- Polymers