Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32719333.
- Also identified by DOI 10.1038/s41467-020-17514-9 and PMC identifier 7385161.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1α, TNFα, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the SOD1<sup>G93A</sup> ALS mouse model, providing evidence for gliosis as a potential ALS therapeutic target.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Astrocytes
- Complement C1q
- Disease Progression
- Interleukin-1alpha
- Tumor Necrosis Factor-alpha