Haplotype networks of SARS-CoV-2 infections in the <i>Diamond Princess</i> cruise ship outbreak.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 32723824.
- Also identified by DOI 10.1073/pnas.2006824117 and PMC identifier 7443927.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The <i>Diamond Princess</i> cruise ship was put under quarantine offshore Yokohama, Japan, after a passenger who disembarked in Hong Kong was confirmed as a coronavirus disease 2019 case. We performed whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR<sup>+</sup> clinical specimens and conducted a phylogenetic analysis of the outbreak. All tested isolates exhibited a transversion at G<sub>11083</sub>T, suggesting that SARS-CoV-2 dissemination on the <i>Diamond Princess</i> originated from a single introduction event before the quarantine started. Although further spreading might have been prevented by quarantine, some progeny clusters could be linked to transmission through mass-gathering events in the recreational areas and direct transmission among passengers who shared cabins during the quarantine. This study demonstrates the usefulness of haplotype network/phylogeny analysis in identifying potential infection routes.
Medical subject headings
- Betacoronavirus
- Coronavirus Infections
- Genome, Viral
- Haplotypes
- Phylogeny
- Pneumonia, Viral
- Ships