Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid.
case_report · Level V
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- Record sourced from PubMed, PMID 32730621.
- Also identified by DOI 10.1093/cid/ciaa1064.
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Abstract
This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 µg/mL and >2.0 µg/mL, respectively.
Medical subject headings
- Mycobacterium tuberculosis
- Nitroimidazoles
- Tuberculosis, Multidrug-Resistant