Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2-Infected Macaques.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32745172.
- Also identified by DOI 10.1093/infdis/jiaa486 and PMC identifier 7454693.
- Licence recorded as CC BY-NC-ND.
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Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
Medical subject headings
- Betacoronavirus
- Coronavirus Infections
- Disease Models, Animal
- Lung Diseases, Interstitial
- Lymphopenia
- Monkey Diseases
- Pneumonia, Viral