MicroRNAs in cartilage development and dysplasia.
review · Level V
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- Record sourced from PubMed, PMID 32745689.
- Also identified by DOI 10.1016/j.bone.2020.115564 and PMC identifier 7502492.
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Abstract
Small regulatory microRNAs (miRNAs) post-transcriptionally suppress gene expression. MiRNAs expressed in skeletal progenitor cells and chondrocytes regulate diverse aspects of cellular function and thus skeletal development. In this review, we discuss the role of miRNAs in skeletal development, particularly focusing on those whose physiological roles were revealed in vivo. Deregulation of miRNAs is found in multiple acquired diseases such as cancer; however congenital diseases caused by mutations in miRNA genes are very rare. Among those are mutations in miR-140 and miR-17~92 miRNAs which cause skeletal dysplasias. We also discuss pathological mechanisms underlining these skeletal dysplasias.
Medical subject headings
- Bone Diseases
- Cartilage
- MicroRNAs