Q-Rank: Reinforcement Learning for Recommending Algorithms to Predict Drug Sensitivity to Cancer Therapy.

Abstract

In personalized medicine, a challenging task is to identify the most effective treatment for a patient. In oncology, several computational models have been developed to predict the response of drugs to therapy. However, the performance of these models depends on multiple factors. This paper presents a new approach, called Q-Rank, to predict the sensitivity of cell lines to anti-cancer drugs. Q-Rank integrates different prediction algorithms and identifies a suitable algorithm for a given application. Q-Rank is based on reinforcement learning methods to rank prediction algorithms on the basis of relevant features (e.g., omics characterization). The best-ranked algorithm is recommended and used to predict the response of drugs to therapy. Our experimental results indicate that Q-Rank outperforms the integrated models in predicting the sensitivity of cell lines to different drugs.