FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data.
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- Record sourced from PubMed, PMID 32761065.
- Also identified by DOI 10.1093/bioinformatics/btaa700 and PMC identifier 8128449.
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Abstract
Transcriptomics dose-response analysis is a promising new approach method for toxicity testing. While international regulatory agencies have spent substantial effort establishing a standardized statistical approach, existing software that follows this approach is computationally inefficient and must be locally installed. FastBMD is a web-based tool that implements standardized methods for transcriptomics benchmark dose-response analysis in R. It is >60 times faster than the current leading software, supports transcriptomics data from 13 species, and offers a comprehensive analytical pipeline that goes from processing and normalization of raw gene expression values to interactive exploration of pathway-level benchmark dose results. FastBMD is freely available at www.fastbmd.ca. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Computational Biology