A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32763179.
- Also identified by DOI 10.1016/j.stem.2020.07.010 and PMC identifier 7717659.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Senescence is a critical factor in several diseases, yet senolytic therapies targeting senescent cells remain hindered by lack of specificity. In the June issue of Nature, Amor et al. (2020) develop chimeric antigen receptor (CAR)-T cells targeting uPAR, a novel senescent-cell marker, to treat liver adenocarcinoma and liver fibrosis.
Medical subject headings
- Cellular Senescence
- T-Lymphocytes