Sowing the Seeds of Clonal Hematopoiesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32763180.
- Also identified by DOI 10.1016/j.stem.2020.07.011.
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Abstract
As humans age, hematopoietic stem cells (HSCs) occasionally acquire mutations in genes including DNMT3A that enable them to outcompete other HSCs and increase leukemia risk. In this issue of Cell Stem Cell, Tovy et al. (2020) report a previously uncharacterized mechanism by which DNMT3A loss confers increased fitness to HSCs by analyzing a rare experiment of nature.
Medical subject headings
- DNA (Cytosine-5-)-Methyltransferases
- Hematopoiesis