Microbial RNAs Pressure Piezo1 to Respond.
editorial · Level V
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- Record sourced from PubMed, PMID 32763186.
- Also identified by DOI 10.1016/j.cell.2020.07.015 and PMC identifier 7880614.
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Abstract
Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.
Medical subject headings
- Gastrointestinal Microbiome
- Serotonin