Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome.
Where this comes from
- Record sourced from PubMed, PMID 32768442.
- Also identified by DOI 10.1016/j.jaci.2020.07.024 and PMC identifier 7862417.
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Abstract
We report on patients with STAT3 loss-of-function (LOF) mutations who developed lupus-like autoimmunity. Immune dysregulation seen in STAT3 LOF patients suggests a susceptibility to systemic autoimmunity with important implications in monitoring and management of these patients.
Medical subject headings
- Autoimmune Diseases
- Job Syndrome
- Lupus Erythematosus, Systemic
- STAT3 Transcription Factor