Simultaneous linear release of folic acid and doxorubicin from ethyl cellulose/chitosan/g-C<sub>3</sub> N<sub>4</sub> /MoS<sub>2</sub> core-shell nanofibers and its anticancer properties.
basic_science · Level V
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- Record sourced from PubMed, PMID 32776414.
- Also identified by DOI 10.1002/jbm.a.37081.
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Abstract
The folic acid (FA) and doxorubicin (DOX) have been doped into the g-C<sub>3</sub> N<sub>4</sub> /MoS<sub>2</sub> incorporated-chitosan/ethyl cellulose (EC) core-shell nanofibers for targeted delivery of FA and DOX against HeLa and MCF-7 cell lines. The g-C<sub>3</sub> N<sub>4</sub> /MoS<sub>2</sub> nanosheets and core-shell nanofibers were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and UV-Vis tests. The drug loading factor, the degradation rate, and the DOX and FA release behavior from core-shell nanofibers have been investigated. The pharmacokinetic results revealed the linear release with non-Fickian diffusion of the both anticancer drugs from nanofibers during 7 days. The DAPI staining and MTT assays of the nanofibers immersed in MCF-7 and HeLa cell lines were studied to determine the potential of DOX and FA doped-core-shell nanofibrous matrix for MCF-7 and HeLa cells death in vitro. The maximum MCF-7 and HeLa cells death percentages were found to be 89 and 85%, respectively, using EC/chitosan/g-C<sub>3</sub> N<sub>4</sub> /MoS<sub>2</sub> /DOX/FA core-shell nanofibers after 7 days. The high activity of g-C<sub>3</sub> N<sub>4</sub> /MoS<sub>2</sub> /DOX/FA loaded-core-shell nanofibers for studied cancer cells killing was achieved.
Medical subject headings
- Antibiotics, Antineoplastic
- Disulfides
- Doxorubicin
- Folic Acid
- Graphite
- Molybdenum
- Nanofibers