A multidimensional precision medicine approach identifies an autism subtype characterized by dyslipidemia.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 32778826.
- Also identified by DOI 10.1038/s41591-020-1007-0.
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Abstract
The promise of precision medicine lies in data diversity. More than the sheer size of biomedical data, it is the layering of multiple data modalities, offering complementary perspectives, that is thought to enable the identification of patient subgroups with shared pathophysiology. In the present study, we use autism to test this notion. By combining healthcare claims, electronic health records, familial whole-exome sequences and neurodevelopmental gene expression patterns, we identified a subgroup of patients with dyslipidemia-associated autism.
Medical subject headings
- Autistic Disorder
- Dyslipidemias
- Precision Medicine