Pregnancy in lymphangioleiomyomatosis: clinical and lung function outcomes in two national cohorts.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 32788260.
- Also identified by DOI 10.1136/thoraxjnl-2020-214987 and PMC identifier 10009819.
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Abstract
Pregnancy in women with lymphangioleiomyomatosis (LAM) has been associated with increased complications and worsening lung function although objective data to advise patients are not available. We assessed lung function and CT scans before and after pregnancy in 16 women with LAM. During the pregnancy, pneumothorax was frequent and mean forced expiratory volume in 1 s (FEV<sub>1</sub>) fell from 77%±19% prepregnancy to 64%±25% predicted and DL<sub>CO</sub> from 66±26 to 57±26 (both p<0.01). After pregnancy, rates of FEV<sub>1</sub> decline were high and 10 patients required sirolimus. Women with LAM, especially with moderate or advanced disease should be counselled regarding adverse events and loss of lung function during the pregnancy.
Medical subject headings
- Lung Neoplasms
- Lymphangioleiomyomatosis
- Pregnancy Complications, Neoplastic