Myeloid Cells TREM Down Anti-tumor Responses.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32822571.
- Also identified by DOI 10.1016/j.cell.2020.07.042.
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Abstract
In this issue of Cell, Molgora et al. and Katzenelenbogen, Sheban, Yalin, et al. highlight the novel role of TREM2 in shaping the immunosuppressive profile of tumor-associated myeloid cells and report that complementing immune-checkpoint therapy with TREM2 blockade induces stronger anti-tumor immune responses and reduces tumor growth.
Medical subject headings
- Neoplasms
- RNA, Small Cytoplasmic