A new channel for the control of renin secretion in juxtaglomerular cells.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 32828234.
- Also identified by DOI 10.1016/j.kint.2020.05.031.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The role of membrane channels in juxtaglomerular cell physiology is only partially understood. Pannexin 1 is a mechanosensitive, nonjunctional channel known for its role in adenosine triphosphate release. The study by DeLalio et al. documents involvement of pannexin 1 in renin secretion by studying mice deficient in pannexin 1 in renin-secreting cells and a prorenin-secreting cell line. Pannexin 1 is believed to suppress renin secretion and thereby modify blood pressure. The commentary addresses the broader physiological implication of these observations for the regulation of renin and blood pressure.
Medical subject headings
- Juxtaglomerular Apparatus
- Renin