Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32831170.
- Also identified by DOI 10.7554/eLife.58042 and PMC identifier 7500950.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.
Medical subject headings
- Long-Term Potentiation
- Receptors, AMPA