Autoantibodies Blocking M<sub>3</sub> Muscarinic Receptors Cause Postganglionic Cholinergic Dysautonomia.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 32833276.
- Also identified by DOI 10.1002/ana.25882 and PMC identifier 7674213.
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Abstract
A 10-year-old girl presented with ileus, urinary retention, dry mouth, lack of tears, fixed dilated pupils, and diffuse anhidrosis 7 days after a febrile illness. We hypothesized that her syndrome was due to autoimmunity against muscarinic acetylcholine receptors, blocking their activation. Using an indirect enzyme-linked immunosorbent assay for all 5 muscarinic receptors (M<sub>1</sub> -M<sub>5</sub> ), we identified in the patient's serum antibodies that selectively bound to M<sub>3</sub> receptors. In vitro functional studies confirmed that these autoantibodies selectively blocked M<sub>3</sub> receptor activation. Thus, autoantibodies against M<sub>3</sub> acetylcholine receptors cause acute postganglionic cholinergic dysautonomia. ANN NEUROL 2020;88:1237-1243.
Medical subject headings
- Autoantibodies
- Primary Dysautonomias
- Receptor, Muscarinic M3