Preventing and treating PTSD-like memory by trauma contextualization.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32839437.
- Also identified by DOI 10.1038/s41467-020-18002-w and PMC identifier 7445258.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms.
Medical subject headings
- Amnesia
- Conditioning, Psychological
- Memory
- Stress Disorders, Post-Traumatic