Steps towards standardized quantification of adult neurogenesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32848155.
- Also identified by DOI 10.1038/s41467-020-18046-y and PMC identifier 7450090.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
New neurons are generated in adult mammals. Adult hippocampal neurogenesis is considered to play an important role in cognition and mental health. The number and properties of newly born neurons are regulatable by a broad range of physiological and pathological conditions. To begin to understand the underlying cellular mechanisms and functional relevance of adult neurogenesis, many studies rely on quantification of adult-born neurons. However, lack of standardized methods to quantify new neurons is impeding research reproducibility across laboratories. Here, we review the importance of stereology, and propose why and how it should be applied to the study of adult neurogenesis.
Medical subject headings
- Brain
- Neural Stem Cells
- Neurogenesis