Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32861017.
- Also identified by DOI 10.1016/j.biomaterials.2020.120339.
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Abstract
The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.
Medical subject headings
- Nanoparticles
- Nanostructures
- Parkinson Disease