Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32868781.
- Also identified by DOI 10.1038/s41467-020-18128-x and PMC identifier 7459304.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart failure-associated ventricular arrhythmia. Comprehensive single-cell resolution analysis identifies the presence of D1R-expressing CMs in both heart failure model mice and in heart failure patients with sustained ventricular tachycardia. Overexpression of D1R in CMs disturbs normal calcium handling while CM-specific deletion of D1R ameliorates heart failure-associated ventricular arrhythmia. Thus, cardiac D1R has the potential to become a therapeutic target for preventing heart failure-associated ventricular arrhythmia.
Medical subject headings
- Arrhythmias, Cardiac
- Heart Failure
- Myocytes, Cardiac
- Receptors, Dopamine D1