Microenvironmental Aspartate Preserves Leukemic Cells from Therapy-Induced Metabolic Collapse.
Where this comes from
- Record sourced from PubMed, PMID 32877685.
- Also identified by DOI 10.1016/j.cmet.2020.08.008.
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Abstract
Metabolic dialogue between tumors and their microenvironment emerges as a key regulator of chemoresistance, the major barrier for the treatment of several cancers. In this issue of Cell Metabolism, van Gastel et al. decipher the pivotal role of stromal glutamine-derived aspartate to sustain pyrimidine biosynthesis in chemoresistant acute myeloid leukemia (AML) and thus state it as a target for anti-cancer therapy.
Medical subject headings
- Drug Resistance, Neoplasm
- Leukemia, Myeloid, Acute